GLP - TZ

What is GLP-TZ?

GLP-TZ (30 mg) is a synthetic peptide designed as a dual agonist of the glucose-dependent insulinotropic polypeptide (GIP) receptor and the glucagon-like peptide-1 (  ) receptor. It is utilized in laboratory research to investigate coordinated incretin signaling and its role in endocrine communication, metabolic regulation, and energy balance.

As a dual incretin receptor agonist, GLP-TZ enables researchers to study how simultaneous activation of GIP and    pathways influences intracellular signaling cascades, receptor cross-talk, and metabolic pathway integration across tissues such as the pancreas, liver, adipose tissue, and skeletal muscle.

GLP-TZ is produced using controlled solid-phase peptide synthesis (SPPS) and purified through high-performance liquid chromatography (HPLC). Analytical verification methods, including mass spectrometry, confirm molecular identity and purity for laboratory research applications.

Note: This compound is intended strictly for laboratory research use only.

Chemical Identity

GLP-TZ consists of a 39–amino acid peptide backbone derived primarily from the endogenous incretin hormone glucose-dependent insulinotropic polypeptide (GIP), with targeted modifications designed to enhance receptor interaction and molecular stability in experimental systems.

The peptide includes a lipid side chain conjugated through a linker region, enabling reversible association with serum albumin. This structural feature influences peptide persistence and stability during laboratory assays and supports its function as a dual receptor agonist in controlled research environments.

Research Applications

Incretin Signaling and Metabolic Pathways

GLP-TZ is widely studied as a molecular tool for investigating incretin signaling networks and hormone-mediated metabolic regulation. By activating both GIP and    receptor systems, it allows researchers to evaluate how coordinated receptor signaling influences intracellular pathways, endocrine communication, and metabolic processes.

Energy Balance and Cellular Metabolism

Laboratory studies frequently examine how incretin receptor activation influences cellular processes related to energy metabolism, nutrient utilization, and metabolic signaling. GLP-TZ enables analysis of cyclic AMP signaling cascades and downstream regulatory pathways associated with metabolic function.

Endocrine and Glucose Signaling

In experimental systems, GLP-TZ is used to study signaling responses in pancreatic and endocrine cell models, including intracellular second messenger activity, kinase pathways, and transcriptional responses involved in glucose-responsive hormone signaling.

Lipid Metabolism and Adipose Biology

Research applications also include investigation of adipose tissue signaling and lipid metabolism. GLP-TZ is used in cellular and preclinical models to evaluate molecular pathways involved in fatty acid processing, lipid storage, and metabolic communication between tissues.

Multi-Tissue Metabolic Integration

Because GLP-TZ activates two incretin receptor systems simultaneously, it is frequently used to study integrated metabolic signaling across multiple organ systems, including liver, pancreas, and skeletal muscle, within controlled experimental environments.

Mechanism of Action

GLP-TZ functions as a dual agonist of GIP and    receptors, both members of the class B G protein–coupled receptor (GPCR) family. Upon receptor binding, it initiates intracellular signaling cascades that regulate cellular metabolism and endocrine signaling pathways.

Target Engagement

GLP-TZ binds to both incretin receptors, inducing conformational changes that activate downstream G protein signaling pathways associated with metabolic regulation.

Downstream Signaling

Activation of these receptors stimulates adenylate cyclase activity, increasing intracellular cyclic AMP levels and triggering downstream signaling pathways involving protein kinase A and transcriptional regulation.

Cellular Effects

In laboratory models, GLP-TZ has been shown to influence intracellular signaling activity, gene expression patterns, and metabolic pathway regulation, making it a valuable research tool for studying receptor pharmacology and metabolic signaling systems.

Comparison: Related Research Compounds

Chemical Properties

View full compound data on PubChem →

Lab Safety & Handling

GLP-TZ should be handled only by trained laboratory personnel following appropriate chemical safety protocols.

• Store lyophilized material at −20°C in a dry, light-protected environment

• Allow vial to reach room temperature before opening

• Use sterile laboratory techniques during preparation

• Avoid repeated freeze–thaw cycles

• Store reconstituted solutions at 2–8°C

Frequently Asked Questions

Why is GLP-TZ studied?
GLP-TZ enables investigation of dual incretin receptor signaling and coordinated metabolic pathways in laboratory environments.

How should it be stored?
Store lyophilized material at low temperatures and protect from moisture and light. Refrigerate after reconstitution.

What is its research use?
GLP-TZ is used for studying incretin biology, receptor pharmacology, and metabolic signaling pathways.

Regulatory & Legal

This product is intended strictly for laboratory research and development use only. It is not approved for human or veterinary use and must not be introduced into humans or animals.

This material is not a drug, food, dietary supplement, or cosmetic and has not been evaluated by the FDA.

Sources & References

1. Min T, Bain SC. View Study
2. Qiao Y, et al. View Study
3. Rees TA, et al. View Study
4. Nauck MA, et al. View Study